Fusarium sp. has rich biodiversity and chemical diversity, and is one of the important sources of active natural products. This review uses a medicinal plant endophyte-Fusarium oxysporum R1 as a reference to compare and analyze the whole genome and secondary metabolite biosynthetic gene cluster of all Fusarium strains in the NCBI database by bioinformatics technology, and predicted the chemical structure type of the secondary metabolites of Fusarium. In addition, this review systematically combs the secondary metabolites derived from Fusarium and their biological activity and biosynthesis report for the first time, and looks forward to further exploring new perspectives on the chemical diversity of Fusarium, providing an important reference for the research and development of new microbial drugs.

Link: https://pubs.rsc.org/en/content/articlelanding/2020/np/d0np00038h#!divAbstract