Recently, our group’s review manuscript, "Targeting Clostridioidesdifficile: New uses for Old Drugs" has been accepted by Drug DiscoveryToday. In this review, we have summarized the new use of old drugs for Clostridioides difficile in detail to provide guidance for clinical treatment of Clostridioides difficile. This work was completed under the guidance of Prof. Wang Hongand Dr. Chen Jianwei. The date of receipt is 2022.3.14. Currently, it is in the proof stage.