Congratulations to master student Wang Xingyue for the acceptance of her article by Organic Letter
Recently, the experimental article titled “Enantioselective Nucleophilic Vinylic Substitution (SNV) Toward 3-Alkenyl-bisoxindoles Facilitated by C6’ Steric Bulk of Cinchona Alkaloid” by Master student Wang Xingyue from the research group has been published online in Organic Letters. The article explores the stereospecific coupling of 3-substituted indoles and (E)-3-(nitromethyl)indole through a C6’ bulky substitution of cinchona alkaloid-catalyzed SNV reaction. This C(sp3)-C(sp2) stereospecific coupling provides a double indole scaffold with a vinyl-substituted all-carbon quaternary stereocenter in high stereochemical selectivity. Additionally, gram-scale synthesis and post-synthetic transformations were performed to demonstrate its potential synthetic utility. The program was guided by Dr. Bao Xiaoze, Professor Damien Boone and Wang Hong.
