副教授，博士生导师。入选浙江工业大学D类人才培育计划。主持国家重点研发项目子课题、国家自然科学基金-面上项目、青年项目以及省部级项目6项，参与国家自然科学基金项目、省重点研发项目等10余项，主持企业横向2项。获协同中心、药学院青年英才项目滚动资助2项。在Adv. Mater. (2篇)、ACS Nano (2篇)、J. Am. Chem. Soc（1篇）、J. Med. Chem.（1篇）、Chem. Eng. J.（1篇）、Chem. Sci. (1篇）以及J. Control. Release（2篇）等国际顶级期刊上共发表论文60余篇，第一作者/通讯作者60余篇，其中3篇为ESI高被引论文，共计引用3200次，授权专利2项。多篇论文发表后被Nat. Biomed. Eng.，JACS，JCM，J. Control. Release，PNAS，Adv. Mater.，Chem. Commun.以及ACS Nano 等高影响力期刊论文正面评述引用。

    主讲《人体解剖学》课程，连续五年获“优课优酬”奖励；先后完成4项校教改，入选校一流课程培育项目，2022年入选浙江省一流本科课程。

    目前担任浙江生命健康联合体青年委员会秘书长，中国肿瘤学纳米肿瘤学专委会青年委员，中国药学会海洋药物药理学会青年委员会常务委员，浙江省药理学会药理学教学专业委员会委员，中国药理学会会员、中国药学会会员、浙江省药学会会员、中国微米纳米技术学会会员，目前担任Sci. Rep., J. Nanomedicine编委，Sci. Adv., Adv. Sci., J. Control. Release, Chem. Eng. J. 以及 Expert. Opin. Drug. Deliv.的杂志审稿人。

教育背景                                                             

2010.9--2014.6    浙江大学                     生物化工               工学博士              导师：申有青教授

2007.9--2010.6    上海第二军医大学       药理学                  医学硕士              导师：姜远英教授

2003.9--2007.6    中国药科大学              药学                      理学学士              导师：王广基教授

工作经历                                                             

2015.01-2016.8     浙江工业大学绿色制药协同创新中心                 讲师

2017.10-2018.10   美国Johns Hopkins（约翰霍普金斯）大学       访问学者

2016.09-至今         浙江工业大学绿色制药协同创新中心                 副教授

主要研究领域                                                                    

1. 基于工程化仿生载体（蛋白、细胞）的构建以及用于抗肿瘤、抗感染以及抗肺纤维化治疗中的研究

2. 海洋来源先导化合物的成药性研究以及剂型开发

论文发表

1. Xinrui Zhang, Xusheng Duan, Xiuzhi Xie, Dan Zhang, Yuan Chen, Ruibing Yu, Yujie Zhou, Yuteng Chu, Jie Shen, Yue Cai*, Xuanrong Sun*. Bioinspired Inhalable Nanoparticles Combining Chinese Herbal Tetandrine with Pirfenidone Overcome Idiopathic Pulmonary Fibrosis via Coordinated Collagen Modulation and Fibroblast Autophagy Regulation. Advanced Healthcare Materials, 2025.21:e01916.

2. Jie Shen, Xinrui Zhang, Jie Wang, Xusheng Duan, junhao pan, Yue Cai, Bin Wei, Hong Wang, Xuanrong Sun*, Targeted Collagen Degradation by an MRI Probe Facilitates siRNA Delivery for Sequential Theranostics in Pulmonary Fibrosis, ACS Nano, 2025, 19(14):14028-14043
   

3. Jie Shen; Xusheng Duan; Ting Xie; Xinrui Zhang; Yue Cai; Junhao Pan; Xin Zhang; Xuanrong Sun* ; Advances in Locally Administered Nucleic Acid Therapeutics, Bioactive Materials, 2025, 49:218-254

4. Yue Cai, Meilin Qiao, Xiuzhi Xie, Yujie Zhou, Ruibing Yu, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun*, Intracellular MRSA-targeted lipid-polymer hybrid nanoparticles for macrophage reprogramming and intracellular MRSA eradication. Chemical Engineering Journal, 2025, 505:159665.

5. Jingyi Lu, Xiaoling Xu, Xuanrong Sun*, Yongzhong Du*, Protein and Peptide-Based Renal Targeted Drug Delivery Systems, Journal of Controlled Release. 2024, 366: 65-84

6. Yue Cai, Yuteng Chu, Yubei Gong, Yulu Hong, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun#.  Enhanced Transdermal Peptide-Modified Flexible Liposomes for Efficient Percutaneous Delivery of Chrysomycin A to Treat Subcutaneous Melanoma and Intradermal MRSA Infection. Advanced Healthcare Materials, 2023, 12(26):e2300881

7. Qianyu Wan, Xinrui Zhang, Dongfang Zhou, Rui Xie, Yue Cai, Kehao Zhang, Xuanrong Sun#, Inhaled nano-based therapeutics for pulmonary fibrosis: recent advances and future prospects. Journal of Nanobiotechnology, 2023, 21(1):215. 

8. Zhikun Yang, Yue Cai, Xue Yang, Xuanrong Sun# et al. Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity[J]. J. Med. Chem. 2023, 66, 8, 5550–5566.

9. Zhikun Yang, Xue Yang, Yasheng Li, Yue Cai, Yanlei Yu, Wenya Zhuang, Xuanrong Sun et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell[J]. European Journal of Medicinal Chemistry, 2023, 257, 5, 115462.

10. Wang Yi, Wang Wenchao, Yu Endian, Zhuang Wenya, Sun Xuanrong, Wang Hong, Li Qingyong, Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and ADME properties, Journal of Nanobiotechnology, 2022, 5; 20(1):402

11. Chen Yan, Liu Pengfu, Wu Jiequn, Yan Wanqing,Xie Saixue, Sun Xuanrong, Ye Bangce, Chu Xiaohe, N-acylhomoserine lactonase-based hybrid nanoflowers: a novel and practical strategy to control plant bacterial diseases, Journal of Nanobiotechnology, 2022, 20, 1.

12. Mengxue Wei, Yixuan Zhou, Mengxia Lin, Jun Zhang, Xuanrong Sun*, Design, synthesis and biological evaluation of rhein-piperazine-dithiocarbamate hybrids as potential anticancer agents. European Journal of Medicinal Chemistry. 2022, 241(5), 114651

13. Shanshan Zheng, Yue Cai, Yubei Gong, Yulu Hong, Licheng Gao, Le Li, Xuanrong Sun*, Legumain/pH Dual-Responsive Lytic Peptide-Paclitaxel Conjugate for Synergistic Cancer Therapy, Drug Delivery, 2022, 29:1, 1764-1775

14. Dabu Zhu, Qiuqin Zhang, Yifang Chen, Minghua Xie, Jianbo Li, Shen Yao, Ming Li, Zhao Lou, Yue Cai, Xuanrong Sun*,  Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity, Drug Delivery. 2022, 29:1,1398-1408

15. Feihu Wang, Hao Su, Dongqing Xu, Maya K. Monroe, Caleb F.Anderson, Weijie Zhang, Richard Oh, Zongyuan Wang, Xuanrong Sun, Han Wang, Fengyi Wan, Honggang Cui. Therapeutic supramolecular tubustecan hydrogel combined with checkpoint inhibitor elicits immunity to combat cancer. Biomaterials. 2021,279

16.  Zhuomin Xu, Shanshan Zheng, Xin Gao, Yulu Hong, Yue Cai, Qiuqin Zhang, Jiani Xiang, Dehui Xie, Fuxing Song, Huawei Zhang, Hong Wang and Xuanrong Sun*, Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability. Journal of Nanobiotechnology, 19:164, 2021

17. Wang, F.; Xu, D.; Su, H.; Zhang, W.; Sun, X.; Monroe, M.; Chakroun, R.W.; Wang, Z.; Dai, W.; Oh, R.; Wang, H.; Wan, F.; Cui, H., Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker-based immunotherapy. Science Advances, 6(18):eaaz8985, 2020.

18. Xinglu Huang, Jie Zhuang, Seung Woo Chung, Buwei Huang, Gilad Halpert, Karina Negron, Xuanrong Sun, Jun Yang, Yumin Oh, Paul M. Hwang, Justin Hanes and Jung Soo Suk. Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia. ACS Nano,13,236-247, 2019.

19. Xuanrong Sun*, Guowei Wang*, Hao Zhang, Shiqi Hu, Xin Liu, Jianbin Tang and Youqing Shen. The Blood Clearance Kinetics and Pathway of polymeric micelles in cancer drug delivery. Acs Nano, 12(6), 6179-6192, 2018. 

20. Xuanrong Sun, Longchao Zhang, Macrophage-mediated delivery of microparticles into tumor hypoxia zones. Journal of Controlled Release, 259，e159, 2017.

21. Xiaoman Mao, Jingxing Si, Qian Huang, Xuanrong Sun, Qianzhi Zhang, Youqing Shen, Jianbin Tang, Xiangrui Liu, Meihua Sui. Self-Assembling Doxorubicin Prodrug Forming Nanoparticles and Effectively Reversing Drug Resistance In Vitro and In Vivo. Advanced Healthcare Materials, 5, 2517-2527, 2016. 

22. Xumeng Wu*, Xuanrong Sun*, Zhiqian Guo, Jianbin Tang, Youqing Shen, Tony D James, He Tian, Weihong Zhu, In Vivo and In Situ Tracking Cancer Chemotherapy by Highly Photostable NIR Fluorescent Theranostic Prodrug. Journal of the American Chemical Society, 136(9), 2579-2588, 2014. 

23. Qihang Sun*, Xuanrong Sun*, Xinpeng Ma, Zhuxian Zhou, Erlei Jin, Bo Zhang, Youqing Shen, Edward A Van Kirk, William J Murdoch, Joseph R. Lott, Timothy P. Lodge, Maciej Radosz and Yuliang Zhao, Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs. Advanced Materials, 26(45):7615-21, 2014.

24. Jingqiang Wang*, Xuanrong Sun*, Meihua Sui, Jianbin Tang, Youqing Shen. Tumor Redox Heterogeneity-Responsive Prodrug Nanocapsules for Cancer Chemotherapy. Advanced Materials, 25, 3670-3676, 2013. 

25. Xuanrong Sun, Zhongchun Chen, Meihua Sui, Jianbin Tang and Youqing Shen. Parallel Synthesis of Polymers from Epoxy-Amine Reaction for Gene Delivery. 2012 Symposium on Innovative Polymers for Controlled Delivery. Journal of Controlled Release, 172, e118, 2012.

26. Erlei Jin, Bo Zhang, Xuanrong Sun, Zhuxian Zhou, Xinpeng Ma,Qihang Sun, Jianbin Tang, Youqing Shen, Edward A Van Kirk,William J Murdoch, Maciej Radosz, Acid Active Cell-Penetrating Peptides for In Vivo Tumor-Targeted Drug Delivery.,Journal of the American Chemical Society, 135, 933-940, 2012. 

授权专利

1. 一种增强金黄霉素A水溶性的组合物及其制备与应用，专利号：202110326317.4

2. 一种抗癌药物组合物，证书号440551