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yang-zhi-kun

杨志昆 管理员

真实姓名: 杨志昆
用户性别: 男
毕业学校: 中国农业大学
用户职称: 讲师
职位分类: 团队老师
办公地址: 子良楼C238
办公单位: 浙江工业大学药学院
团队职位: 课题组老师

个人简介

海洋药物团队大合影

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海药药化小组合影

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个人Researchgate网页: https://www.researchgate.net/profile/Zhikun-Yang-3

学习与工作经历

  1. 2011.09-2015.07， 郑  州  大  学，学士，导师：冶保献 教授
  2. 2015.09-2017.07，中国农业大学，硕士，导师：刘尚钟 教授
  3. 2017.09-2021.07，中国农业大学，博士，导师：王保民 教授
  4. 2021.07-2023.11，浙江工业大学，药学院，博士后，导师：王鸿 教授
  5. 2024.01-   至   今，浙江工业大学，药学院，讲师

研究方向

       聚焦于药物化学领域，致力于海洋天然产物（CADD/AIDD）及靶向药物（XDCs、PROTACS）开发、抗肿瘤/细菌多药耐药研究。浙江省药学会海洋药物专委会青年委员、中国化学会会员。主持国家自然科学基金青年基金项目和浙江省自然科学基金探索项目各1项，参与国家重点研发计划、国际(地区)合作与交流和企业横向合作等多个项目，在Angew. Chem.、J. Med. Chem. 、Eur. J. Med. Chem. 、J. Agr. Food Chem.、Bioorg. Chem.、J. Enzym. Inhib. Chem. 等知名国际刊物发表论文30余篇, 其中以第一作者或通讯作者身份发表论文12余篇，授权专利5项；现为期刊Pharmaceutical Science Advances青年编委，期刊 J. Agr. Food Chem.、Molecules审稿人。  

教学与育人情况

       辅讲本科生课程《海洋药物学》、《天然药物化学》和留学生《海洋药物学》课程。合作培养在读研究生7人（博士生4人、硕士生3人），其中1人获研究生国家奖学金；合作指导本科生10余人，累计完成指导本科生毕业生7人。

代表性研究成果和学术奖励情况

一、代表性论著：

  1. Zhikun Yang, Yue Cai, Xue Yang, Yasheng Li, Qihao Wu, Yanlei Yu, Zhen Chen, Bin Wei, Jinmiao Tian, Xiaoze Bao, Xinyi Ye, Jianwei Chen, Huawei Zhang, Xiaozhou Mou, Xuanrong Sun, Hong Wang. Novel Benzo Five-Membered Heterocycle Derivatives as P‑Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity. J. Med. Chem., 2023, 66:5550-5566. (DOI: 10.1021/acs.jmedchem.2c01999).
  2. Wei Hou, Xiaohui Zhou, Zhikun Yang, Huhui Xia, Yan Wang, Keren Xu, Shaoneng Hou, Shuning Zhang, Dongmei Cui, Peixiang Ma, Wei Zhou, Hongtao Xu. Multicomponent Reaction Integrating Selenium(II)–Nitrogen Exchange (SeNEx) Chemistry and Copper‐Catalyzed Azide–Alkyne Cycloaddition (CuAAC). Angew. Chem. Int. Edit., 2025, e202500942.(DOI: 10.1002/anie.202500942). (共同一作).
  3. Zhikun Yang, Disheng Luo, Chen Shao（本科生）, Haoqiang Hu, Xue Yang, Yue Cai, Xiaozhou Mou, Qihao Wu, Hongtao Xu, Xuanrong Sun, Hong Wang, Wei Hou. Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2024, 268:116207.
  4. Zhikun Yang, Yue Cai, Shen Mao, Qihao Wu, Mengdi Zhu, Xiaoji Cao, Bin Wei, Jinmiao Tian, Xiaoze Bao, Xinyi Ye, Jianwei Chen, Sijia Wang, Yanlei Yu, Huawei Zhang, Xuanrong Sun, Zining Cui, Yasheng Li, Hong Wang. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2023, 257:115462 (DOI: 10.1016/j.ejmech.2023.115462).
  5. Zhikun Yang, Xue Yang, Yasheng Li, Yue Cai, Yanlei Yu, Wenya Zhuang, Xuanrong Sun, Qingyong Li, Xiaoze Bao, Xinyi Ye, Jinmiao Tian, Bin Wei, Jianwei Chen, Qihao Wu, Huawei Zhang, Xiaozhou Mou, Hong Wang. Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2023, 248:115092 (DOI: 10.1016/j.ejmech.2023.115092).
  6. Zhikun Yang, Qibo Li, Jiaming Yin, Ruiquan Liu, Hao Tian, Liusheng Duan, Zhaohu Li, Baomin Wang, Weiming Tan, Shangzhong Liu. Design, Synthesis, and Mode of Action of Novel 3-Chloro-6-Pyrazolyl-Picolinate Derivatives as Herbicide Candidates. Pest Manag. Sci., 2022, 77:2252-2263 (DOI: 10.1002/ps.6250).
  7. Keren Xu（本科生）, Leyi Ying, Titi Ying, Qihao Wu, Lin Du, Yanlei Yu, Youmin Ying, Bin Wei, Hong Wang, Zhikun Yang. Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. J. Enzym. Inhib. Med. Chem., 2024, 39(1):2387415 (DOI: 1080/14756366.2024.2387415).
  8. Zhi Huang（本科生）, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li, Hong Wang. Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents. Results Chem., 2022, 4:100391 (DOI: 10.1016/j.rechem.2022.100391). (共同一作).
  9. Zhikun Yang, Jiahui Xu, Lin Du, Jiaming Yin, Zhao Wang, Mujahid Hussain, Liusheng Duan, Zhaohu Li, Baomin Wang, Kai Shu, Weiming Tan. Design, Synthesis, and Action Mechanism of 1,3-Benzodioxole Derivatives as Potent Auxin Receptor Agonists and Root Growth Promoters. Front. Plant Sci., 2022, 13:902902 (DOI: 10.3389/fpls.2022.902902).
  10. Zhikun Yang, Jiahui Xu, Yumeng Bai, Zhao Wang, Liusheng duan, Weiming Tan. Design, Synthesis and Gibberellin-like Activity Study of Novel 1- Substituted -3-(3-(trifluoromethyl) phenyl) Thiourea Derivatives. J. Plant Growth Regul., 2021, 41:1845-1853 (DOI: 10.1007/s00344-021-10425-z).
  11. Zhikun Yang, Linghui Zhu, Hao Tian, Jine Wang, Jiaming Yin, Liusheng Duan, Weiming Tan. Design, Synthesis and Biological Activities of Novel Urea Derivatives with Superior Plant Growth-Inhibiting Activity. Plant Growth Regul., 2021,93:243-252 (DOI: 10.1007/s10725-020-00682-5).

二、代表性专利：

  1. 王鸿; 杨志昆; 鲍晓泽; 田金淼; 叶欣艺;   一种苯基呋喃-四氢异喹啉类化合物及其制备与应用,  2024-11-5, 中国, ZL 2022 1 1389431.2 (专利）
  2. 王鸿; 杨志昆; 邵晨（本科生）; 蔡荣荣（本科生）; 王渴欣（本科生）; 叶欣艺; 鲍晓泽; 陈华；一种苯基萘类化合物及其制备与应用, 2024-9-3, 中国, ZL 2023 1 1119963.9 (专利）
  3. 王鸿; 杨志昆; 李庆勇; 田金淼; 叶欣艺; 鲍晓泽;  一种苯基吲哚类化合物及其制备与应用, 2024-3-26, 中国, ZL 2022 1 1389414.9 (专利）
  4. 王鸿; 杨志昆; 俞琰垒; 陈建伟; 魏斌; 叶欣艺; 鲍晓泽; 田金淼 ; 一种苯甲酰胺类化合物及其制备与应用, 2024-2-13, 中国, ZL 2022 1 1389421.9 (专利）
  5. 谭伟明; 杨志昆; 朱灵慧; 段留生 ; 一种苄硫基乙酰胺类化合物及其制备方法与应用, 2021-7-9, 中国, ZL 201911366906.4 (专利)