博士，硕士生导师，浙江工业大学海洋药物创新团队核心成员，主要从事药物化学领域的科学研究工作，重点聚焦海洋天然产物智能开发及抗肿瘤/细菌研究。浙江-埃及海洋药物智能发现联合实验室骨干，浙江省药学会海洋药物专委会青年委员、中国化学会会员。主持或参与国家自然科学基金、浙江省自然科学基金、国家重点研发计划、国家自然科学基金国际（地区）合作和企业横向合作等多个项目，在Angew. Chem. Int. Ed.、Nat. Commun.、J. Med. Chem.、Eur. J. Med. Chem等国际知名刊物发表论文40余篇, 其中以第一作者或通讯作者身份发表论文20余篇，授权专利6项；现为Pharm. Sci. Adv.、Food Med. Homol.、MarineMedicine等期刊青年编委，Nat. Commun.、J. Agr. Food Chem.、Eur. J. Med. Chem等期刊审稿人。

海洋药物团队和小组合影

个人Researchgate网页: https://www.researchgate.net/profile/Zhikun-Yang-3

学习与工作经历

• 2011.09-2015.07， 郑  州  大  学，化学系，学   士，导师：冶保献 教授
• 2015.09-2017.07，中国农业大学，理学院，硕   士，导师：刘尚钟 教授
• 2017.09-2021.07，中国农业大学，农学院，博   士，导师：王保民 教授
• 2021.07-2023.11，浙江工业大学，药学院，博士后，导师：王鸿 教授
• 2024.01-至      今，浙江工业大学，药学院，助理研究员

研究方向

1. 海洋特色肿瘤多药耐药逆转剂的智能开发；

2. 海洋来源抗肿瘤/菌活性分子的智能优化（小分子、PROTACs）；

3. 靶向药物（PDCs、DPCs）开发。

教学与育人情况

       辅讲本科生课程《药物化学》、《天然药物化学》、《海洋药物学》等课程；主讲研究生《制药企业研发案例分析》，辅讲研究生《天然药物高效制备技术》。合作培养研究生 13人（在读：博士生4人、硕士生 7人；毕业：硕士生 2人），其中 4人获研究生国家奖学金；合作指导本科生20余人，其中，多名同学至浙江大学、上海药物所、西湖大学等继续深造，已累计完成指导本科生毕业生10余人。

代表性研究成果和学术奖励情况

一、近五年代表性论著：

1. Leyi Ying, Xin Yu, Lei Li, Jiajia Han, Keren Xu, Yuxing Yao, Wenchao Wang, Yi Hua, Yanlei Yu, Hua Chen, Xiaoze Bao, Qingyong Li, Qihao Wu, Zhikun Yang*, and Hong Wang. AI-Guided Discovery of Natural-Product-Inspired Scaffolds as Dual P‑gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance. J. Med. Chem., 2026, 69:21044–21061.(DOI: 10.1021/acs.jmedchem.6c00742).
2. Keren Xu, Zekai Cui, Yingjia Ding, Tao Guo, Jiajia Han, Yuxing Yao, Yue Cai, Bin Wei, Xiaoze Bao, Hua Chen, Yi Hua, Qihao Wu,* Hong Wang,* and Zhikun Yang*. Gut Bacterial β-Glucuronidase Blockade by 1,3,4-Thiadiazole-Containing Thioester Inhibitors Mitigates Irinotecan-Induced Gastrointestinal Toxicity. J. Med. Chem., 2026, 69:18300-18314. (DOI: 10.1021/acs.jmedchem.6c02170).
   
3. Zhikun Yang, Yue Cai, Xue Yang, Yasheng Li, Qihao Wu, Yanlei Yu, Zhen Chen, Bin Wei, Jinmiao Tian, Xiaoze Bao, Xinyi Ye, Jianwei Chen, Huawei Zhang, Xiaozhou Mou, Xuanrong Sun*, Hong Wang*. Novel Benzo Five-Membered Heterocycle Derivatives as P‑Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity. J. Med. Chem., 2023, 66:5550-5566. (DOI: 10.1021/acs.jmedchem.2c01999).
4. Wei Hou#, Xiaohui Zhou#, Zhikun Yang#, Huhui Xia, Yan Wang, Keren Xu, Shaoneng Hou, Shuning Zhang, Dongmei Cui, Peixiang Ma, Wei Zhou*, Hongtao Xu*. Multicomponent Reaction Integrating Selenium(II)–Nitrogen Exchange (SeNEx) Chemistry and Copper‐Catalyzed Azide–Alkyne Cycloaddition (CuAAC). Angew. Chem. Int. Edit., 2025, e202500942.(DOI: 10.1002/anie.202500942). (共同一作).
5. Junjie Ge, Lihang Cao, Kun Lin, Chenhao Ruan, Xinyi Ye, Xiaoze Bao, Zhikun Yang*, Hong Wang*, Hua Chen*. Ring Expansion of Bicyclo[1.1.0]butyl Ketones to Bicyclo[2.1.1]hexenes Using Ketone as Both Activating and Reacting Groups. Nat. Commun., 2025, 16, 9190. (DOI: 10.1038/s41467-025-64226-z).(共同通讯).
6. Zekai Cui, Tao Guo, Keren Xu, Zhengyi Xie（本科生）, Mahmoud Emam, Hong Wang*, Zhikun Yang*. Pharmacological activities, SARs and targets of heterocyclic derivatives as QSIs against bacteria multidrug resistance. Eur. J. Med. Chem., 2026, 316:119036（DOI: 10.1016/j.ejmech.2026.119036）.
7. Zhikun Yang, Disheng Luo, Chen Shao（本科生）, Haoqiang Hu, Xue Yang, Yue Cai, Xiaozhou Mou, Qihao Wu, Hongtao Xu, Xuanrong Sun, Hong Wang, Wei Hou*. Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2024, 268:116207（DOI: 10.1016/j.ejmech.2024.116207）.
   
8. Zhikun Yang, Yue Cai, Shen Mao, Qihao Wu, Mengdi Zhu, Xiaoji Cao, Bin Wei, Jinmiao Tian, Xiaoze Bao, Xinyi Ye, Jianwei Chen, Sijia Wang, Yanlei Yu, Huawei Zhang, Xuanrong Sun, Zining Cui*, Yasheng Li*, Hong Wang*. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2023, 257:115462 (DOI: 10.1016/j.ejmech.2023.115462).
   
9. Zhikun Yang, Xue Yang, Yasheng Li, Yue Cai, Yanlei Yu, Wenya Zhuang, Xuanrong Sun, Qingyong Li, Xiaoze Bao, Xinyi Ye, Jinmiao Tian, Bin Wei, Jianwei Chen, Qihao Wu, Huawei Zhang, Xiaozhou Mou*, Hong Wang*. Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell. Eur. J. Med. Chem., 2023, 248:115092 (DOI: 10.1016/j.ejmech.2023.115092).
10. Zimeng Huang（本科生）, Yijing Du（本科生）, Junzhe Hu（本科生）, Leyi Ying, Binying Zhou（本科生）, Yi Hua, Hong Wang*, Zhikun Yang*. Marine Natural Products as Potent Anticancer Agents (2020–2024): Structural Diversity, SARs and Target Prediction. Mar. Drugs, 2026, 24:173. (DOI: 10.3390/md24050173).
    
11. Zhikun Yang, Leyi Ying, Ning Yang, Xue Yang, Hui Yan, Jiajia Han, Yanhong Yang, Xiaozhou Mou*, Hong Wang*, Yasheng Li*. Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cell.  Bioorg. Chem., 2025, 164: 108854. (DOI: 10.1016/j.bioorg.2025.108854).
12. Keren Xu（本科生）, Leyi Ying, Titi Ying, Qihao Wu, Lin Du, Yanlei Yu, Youmin Ying, Bin Wei, Hong Wang*, Zhikun Yang*. Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. J. Enzym. Inhib. Med. Chem., 2024, 39(1):2387415. (DOI: 10.1080/14756366.2024.2387415).
    
13. Zhikun Yang, Yingjia Ding, Keren Xu, Jiajia Han, Junzhe Hu, Sherien M. Bakry, Yi Hua, Hong Wang*. Design, synthesis, and biological evaluation of novel phenylindole derivatives as P-gp inhibitors to overcome multidrug resistance in MCF-7/ADR cells. Bioorg. Med. Chem., 2026, 143, 118789. (DOI: 10.1016/j.bmc.2026.118789).
    
14. Zhikun Yang, Jiajia Han, Yanhong Yang, Xue Yang, Yijing Du, Zimeng Huang, Leyi Ying, Xin Yu, Yi Hua, Qihao Wu, Xiaozhou Mou*, Hong Wang*. Rational discovery of novel phenylindole-bisamide derivatives as potent P-glycoprotein inhibitors for cancer multidrug resistance. RSC Med. Chem., 2026, 17, 2455 - 2472. (DOI: 10.1039/d6md00030d).
    
15. Zhikun Yang, Yanhong Yang, Zimeng Huang, Yi Hua, Mahmoud Emam, Hong Wang*. Development of Heterocyclic Derivatives as P-Glycoprotein Inhibitors Against Multidrug Resistance:Pharmacological Activities, Structure-activity Relationship and Target (2020-2024). RSC Med. Chem., 2025, 16, 4617 - 4656. (DOI: 10.1039/d5md00609k).
16. Zhi Huang（本科生）, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li*, Hong Wang*. Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents. Results Chem., 2022, 4:100391 (DOI: 10.1016/j.rechem.2022.100391). (共同一作).
    
17. Zhikun Yang, Qibo Li, Jiaming Yin, Ruiquan Liu, Hao Tian, Liusheng Duan, Zhaohu Li, Baomin Wang, Weiming Tan*, Shangzhong Liu*. Design, Synthesis, and Mode of Action of Novel 3-Chloro-6-Pyrazolyl-Picolinate Derivatives as Herbicide Candidates. Pest Manag. Sci., 2022, 77:2252-2263. (DOI: 10.1002/ps.6250).
    
18. Zhikun Yang, Jiahui Xu, Lin Du, Jiaming Yin, Zhao Wang, Mujahid Hussain, Liusheng Duan, Zhaohu Li, Baomin Wang, Kai Shu*, Weiming Tan*. Design, Synthesis, and Action Mechanism of 1,3-Benzodioxole Derivatives as Potent Auxin Receptor Agonists and Root Growth Promoters. Front. Plant Sci., 2022, 13:902902. (DOI: 10.3389/fpls.2022.902902).

二、代表性专利：

1. 杨志昆；徐可人；王鸿；魏斌；俞琰垒；一种脲或硫脲类化合物及其制备与应用，2026‑08‑14, 中国，ZL 2024 1 0949580.2 (专利）
2. 王鸿; 杨志昆; 鲍晓泽; 田金淼; 叶欣艺;   一种苯基呋喃-四氢异喹啉类化合物及其制备与应用,  2024-11-5, 中国, ZL 2022 1 1389431.2 (专利）
   
3. 王鸿; 杨志昆; 邵晨（本科生）; 蔡荣荣（本科生）; 王渴欣（本科生）; 叶欣艺; 鲍晓泽; 陈华；一种苯基萘类化合物及其制备与应用, 2024-9-3, 中国, ZL 2023 1 1119963.9 (专利）
4. 王鸿; 杨志昆; 李庆勇; 田金淼; 叶欣艺; 鲍晓泽;  一种苯基吲哚类化合物及其制备与应用, 2024-3-26, 中国, ZL 2022 1 1389414.9 (专利）
   
5. 王鸿; 杨志昆; 俞琰垒; 陈建伟; 魏斌; 叶欣艺; 鲍晓泽; 田金淼 ; 一种苯甲酰胺类化合物及其制备与应用, 2024-2-13, 中国, ZL 2022 1 1389421.9 (专利）
   
6. 谭伟明; 杨志昆; 朱灵慧; 段留生 ; 一种苄硫基乙酰胺类化合物及其制备方法与应用, 2021-7-9, 中国, ZL 201911366906.4 (专利)