Recently, doctor Zhikun Yang's research article entitled "Novel Benzo Five-membered Heterocycle Derivatives as P-glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-multidrug Resistance Activity", accepted by Journal of Medicinal Chemistry (IF: 8.039). In this paper, a novel P-gp inhibitor d7 was reasonably designed by using  classical drug design concepts, combined with computer-aid drug discovery and bioinformatics. Compound d7 can effectively reverse multidrug resistance of breast cancer cells in vivo and in vitro, and it is non-toxic, which has great application potential. Professor Hong Wang and associate professor Xuanrong Sun are the co-corresponding authors.